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    • 06 FEB 19

    Publication in “Clinical Infectious Diseases”: a study conducted by scientists, among them Institut Pasteur du Cambodge researchers

    A recent and important Scientific Publication, in “Clinical Infectious Diseases” : “Isolation of Non-tuberculous Mycobacteria in South-East Asian and African HIV-infected Children with Suspected Tuberculosis”.
    Nontuberculous mycobacteria (NTM) are saprophytic organisms present in the environment, and are not systematically pathogenic but can cause various diseases in humans. A study conducted by scientists, among them Institut Pasteur du Cambodge researchers, assessed the rate of NTM isolation in HIV-infected children with a clinical suspicion of tuberculosis in a prospective cohort followed in 4 countries with high and very high tuberculosis burden, as well as NTM species distribution and factors associated with NTM isolation.
    In this context, were enrolled 427 human immunodeficiency virus–infected children (median age, 7.3 years), 59.2% severely immunodeficient, with suspected tuberculosis in Southeast Asian and African settings. Nontuberculous mycobacteria were isolated in 46 children (10.8%); 45.7% of isolates were Mycobacterium avium complex. Southeast Asian origin, age 5–9 years, and severe immunodeficiency were independently associated with nontuberculous mycobacteria isolation.