Title: “Mechanisms of sex determination in malaria parasites”
Speaker: Dr Arthur Talman
Malaria is caused by parasites of the genus Plasmodium. Whilst the disease is caused by asexual parasites, only sexual forms are capable of transmitting the infection to mosquitoes. Only a small subset of blood-stage parasites divert from the cycle of asexual replication and embark on a sexual developmental trajectory. The developmental bifurcation leading to a sexual fate is dependent on the master regulator of sex, the transcription factor AP2-G. In the absence of sex chromosomes or conserved sex-determining mechanisms, events that lead to determination into either a male or a female are completely unknown. Here, we used single-cell technology and highly parallel phenotyping, as well as reverse genetics, to identify and characterise genes involved in the sex-determining pathway of malaria parasites. We are currently extending these findings and assessing how sex determination is influenced by environmental variation, which is best measured in natural environments, we are therefore investigating the sex-determining pathway directly in naturally-infected carriers in Cameroon, using scRNAseq. Not only can this establish the natural variation in sex-determination expression patterns, but it may also identify parasite and host factors, which play a role in the environmental determination of sex. Targeting sex-determination to generate sterile parasites has the potential to interrupt transmission.
Location: Institut Pasteur in Cambodia: Meeting room, 1st floor,
Meeting room door closed at 02:05 PM
December 2nd, 2019 – 02:00 PM
Fee: Free Entry
THANKS TO CONFIRM YOUR PARTICIPATION: [email protected]