* Please click here to see ANRS 12229 Protocol
Childhood tuberculosis (TB) accounts for 11% of the total 9 million annual TB cases and is still not considered a public health priority in endemic countries, since its paucibacillary forms contribute little to the transmission of the disease. The difficulty of diagnosing TB in children is increased in case of HIV infection, in a situation of very high morbidity and mortality and major therapeutic and care issues. The tests currently available as well as diagnostic approaches recommended by the national programs or WHO are not sufficiently sensitive and specific. PAANTHER 01 is a multicentre diagnosis study based on a longitudinal and prospective follow-up of a cohort of 420 HIV-infected children suspect of intra-thoracic TB, diagnosed and treated according to national guidelines after clinical, radiological and bacteriological characterization.
It is conducted in Asia (Cambodia, Vietnam) and in Africa (Burkina Faso, Cameroon) to develop a diagnostic algorithm aiming to improve the diagnosis of tuberculosis in HIV-infected children in the context of developing countries with high tuberculosis endemicity.
To Oct. 1st, 2012, a total of 79 children have been included in Cambodia.
The PAANTHER 01 study is sponsored by the ANRS (ANRS 12 229).