The Immunology research at Institut Pasteur Cambodia focuses on the immune answer of the human host to pathogen infection. Immediately after an infection, the host innate immune system activates different lines of protective mechanisms in order to stop the spreading of the pathogen, eliminate infected cells and initiate the adaptive immune response. Antigen specific B and T cells get activated in secondary lymphoid organs with the generation of cytotoxic CD8+ T-cells and antibody producing plasmacells.
Our main research interests are:
1/ Mechanisms of host-pathogen interaction (on a cellular and molecular level) 2/ The contribution of the immune response to disease severity 3/ Immune correlations of disease severity (biomarker discovery)
Our research emphasizing on pathogen interactions in the human host may lead to better diagnostic tools, the development of vaccines, and the identification of new targets for drug design. On of our main strengths is the availability of fresh human samples giving us the opportunity to perform in-depth mechanistic studies.
The Immunology research at Institut Pasteur Cambodia consists of 2 research teams:
1/ Immunology platform
The immunology platform brings its expertise in research programs on the innate response to microbial infections such as HIV / AIDS, dengue and tuberculosis, in collaboration with the clinical research pole in the Epidemiology and public health unit, Virology unit and HIV / Hepatitis unit. It conducts its own research, in particular on the inflammatory responses which occur in some patients co-infected with HIV and tuberculosis in the context of collaborative projects in the Institut Pasteur International Network.
2/ Immunology Group (G4)
Individuals suffering from dengue virus (DENV) infection can have a wide variety of disease manifestations ranging from no symptoms at all, to dengue fever or severe disease leading to hospitalization with life-threatening complications. The host mechanisms that govern this differential response to infection are not well understood. It is clear, however, that the adaptive immune response has a major role in the development of severe dengue disease. The aim of our group is to investigate the role of protective versus detrimental adaptive immune responses in dengue viral infection (both primary and secondary infection).