Established in 2015, the Immunology Group is a new research group at IP Cambodia, funded by the Pasteur International Network, determined to unravel the adaptive immune responses during viral infection with focus on neglected tropical diseases. In this context, B cells have been mainly regarded as the precursors of neutralizing antibody secreting plasma cells. However, B cells perform many other functions, such as antigen presentation, costimulation and cytokine production, and have important immunomodulatory functions, as shown by us and others.
In addition, antibodies can have immunomodulatory functions as well. We are interested to define the mechanisms by which B cells and antibodies contribute to disease immunopathogenesis during viral infections. In this framework, we are investigating the functional response of B cells during secondary flavivirus infection and after post-exposure rabies prophylaxis.
Our latest publication made the cover of Science Translational Medicine!