5 Monivong Boulevard, P.O Box. 983, Phnom Penh, Cambodia [email protected]

I have always been interested in studying inter-specific interactions in an eco-evolutionary framework.

During my pre-doctoral studies in Paul Sabatier University (Toulouse, France), I have worked on various subject such as the biology and ecology of fire ants in the tropical forest of French Guiana, the costs and benefits of the parabiotic association between two ant species found in ant gardens, or characterizing the nature of the interaction between a ladybird larva and an invasive ant species. For my PhD I have joined the laboratory of entomology in Leuven (Belgium) to study an ant-aphid mutualism and the possible existence of cheaters of this mutualism.

After very ant-based researches, I have moved toward Anopheles mosquitoes-malaria parasites interaction. I have joined Thierry Lefèvre and Anna Cohuet from the MIVEGEC laboratory (IRD) to work in Burkina Faso. My researches were aiming at better understanding the influence of environmental factors on this host-parasite interaction.
In 2014, I have joined the Pasteur Institute in Cambodia under the supervision of Didier Ménard after obtaining a two years post-doctoral Pasteur Paris grant to focus on the role of vectorial transmission on the evolution of Plasmodium falciparum artemisinin resistance. Thanks to the setting-up of an insectary, an experimental infection platform and the training of technicians in entomology, we are now developing various aspect of malaria transmission studies.
We are interested in malaria mosquito ecology and behavior, using notably odor-baited traps we aim at better characterizing Anopheles vector behaviors (host choice) and activity rhythms to inform novel vector control tools development. We are linking these studies to the effects of rapid environmental changes such as deforestation or agriculture through sampling in various environments, as well as investigating human behavior through space and time to assess human exposure to mosquito bites. A second aspect of our researches focuses on the infectivity of symptomatic and asymptomatic malaria parasite carriers to mosquitoes as well as studying malaria parasite development in its mosquito host and undertaking liver stage drug screening.

Email: [email protected]; [email protected]

Reprints available upon request

2020

Vantaux A., Kim S., Piv E., Chy S., Berne L., Khim N., Lek D., Siv S.,Mukaka M., Talyor W. R. and Ménard D. 2020. Significant efficacy of single low dose primaquine compared to stand alone artemisinin combination therapy in reducing gametocyte carriage in Cambodian patients with uncomplicated multidrug resistant Plasmodium falciparum malaria. Antimicrobial Agents and Chemotherapy. 64:e02108-19.
Popovici J., Roesch C., Carias L. L., Khim N., Kim S., Vantaux A., Mueller I., Chitnis C. E., King, C. L., Witkowski B. 2020. Amplification of Duffy Binding Protein-encoding gene allow Plasmodium vivax to evade host-anti-DBP humoral immunity. Nature Communications 11 : 953.
Posfai D., Maher S. P., Roesch C., Vantaux A., Sylvester A., Péneau J., Popovici J., Kyle D., Witkowski B. Derbyshire E. R. 2020. Plasmodium vivax liver and blood stages recruit the druggable host membrane channel aquaporin-3. Cell Chemical Biology. 27: 719-727.

2019

Baragana B., Forte B., Choi R., Nakazawa Hewitt S., Bueren-Calabuig J., Pisco J. P., Peet C., Dranow D., Robinson D. A., Jansen C., Norcross N. R., Vinayak S., Anderson M, Brooks C., Cooper C., Damerow S., Delves M., Dowers K., Duffy J., Edwards T., Hallyburton I., Horst B., Hulverson M, Ferguson L., Jimenez-Diaz B., Jumani R. S., Lorimer D. D., Love M. S., Maher S., Matthews H., McNamarra C., Miller P., O-Neill S., Ojo K. K., Osuno-Cabello M., Pinto E., Post J., Riley J., Rottmann M., Sanz-Alonso L. M., Scullion P., Sharma A., Shepherd S. M., Shishikura Y., Simeons F. R. C., Stebbins E. E., Stojanovski L., Straschil U., Tamaki F. K., Tamjar J., Torrie L. S., Vantaux A., Witkowski B., Wittlin S., Yogavel M., Zuccotto F., Angulo-Barten I., Sinden R. E., Baum J., Gamo-Benito J., Maser P., Kyle D. E., Winzeler E. A., Myler P. J., Wyatt P., Floyd D. M., Matthews D. A., Sharma A., Striepen B., Huston C. D., Gray D. W., Fairlamb A. H., Pisliakov A., Walpole C., Read K. D., Van Voorhis W. C. and Gilbert I. H. Lysyl-tRNA synthetas as a drug target in malaria and cryptosporidiosis. 2019. Proceedings of the National Academy of Sciences of the United States of America. 116: 7015-7020.
Belda E., Nanfack Minkeu F., Eiglmeier K., Holm I., Carissimo G., Holm I., Diallo M., Diallo D., Vantaux A., Kim S., Sharakhov I. V. and Vernick K. D. 2019. De novo profiling of RNA viruses in Anopheles malaria vector mosquitoes from forest ecological zones in Senegal and Cambodia. BMC Genomics. 20 : 664.

2018

Vantaux A., Yao F., de Sales Hien F. D., Guissou E., Yameogo B. K., Gouagna L.-C., Fontenille D., Renaud F., Simard F., Costantini C., Thomas F., Mouline K., Roche B., Cohuet A., Dabiré K. R. and Lefèvre T. 2018. Field evidence for manipulation of mosquito host selection by the human malaria parasite. bioRxiv, 207183, ver. 6 recommended and peer-reviewed by PCI Evolutionary Biology. doi: 10.1101/207183.
Bilgo E., Vantaux A., Sanon A., Ilboudo S., Dabiré R. K., Jacobs-Lorena M. and Diabaté A. 2018. Field assessment of potential sugar feeding stations for disseminating bacteria in a paratransgenic approache to control malaria. Malaria Journal, 17: 367.
Popovici J., Vantaux A., Primault L., Samreth R., Piv E., Bin S., Kim S., Lek D., Serre D. and Ménard D. 2018. Therapeutic and transmission-blocking efficacy of dihydroartemisinin-piperaquine and chloroquine in Plasmodium vivax malaria, Cambodia. Emerging Infectious Diseases, 24: 1516-1519.
Roth A., Maher S., Conway A. J., Ubalee R., Chaumeau V., Andolina C., Kaba S. A., Vantaux A., Bakowski M. A., Thomson Luque R., Adapa S. R., Singh N., Barnes S. J., Cooper C. A., Rouillier M., McNamara C. W., Mikolajczak S. A., Sather N., Witkowski B, Campo B., Kappe S. H. I., Lanar D. E., Nosten F., Davidson S., Jiang R. H. Y., Kyle D. E. and Adams J.H. 2018. A comprehensive model for assessment of liver stage therapies targeting Plasmodium vivax and Plasmodium falciparum. Nature Communications, 9: 1837.
Vantaux A., Samreth R., Piv E., Khim N., Kim S., Berne L., Chy S., Lek D., Siv S., Talyor W. R. and Ménard D. 2018 Contribution to malaria transmission of symptomatic and asymptomatic parasite carriers in Cambodia. Journal of Infectious Diseases, 217: 1561-1568.

2017

Vantaux A.*, Nguyen P.*, de Sales Hien F. D., Dabiré K. R., Yameogo B. K., Gouagna L.-C., Fontenille D., Renaud F., Simard F., Costantini C., Thomas F., Cohuet A. and Lefèvre T. 2017. No evidence for manipulation of An. gambiae, An. coluzzii and An. Arabiensis host preference by Plasmodium falciparum. Scientific Reports. 7: 9415
* These authors contributed equally.
Kim A., Popovici J., Vantaux A., Samreth R., Bin S., Kim S., Roesch C., Liang L., Davies H., Felgner P., Herrera S., Arévalo-Herrera M., Ménard D.and Serre D. 2017 Characterization of P. vivax blood stage transcriptomes from field isolates reveals similarities among infections and complex gene isoforms. Scientific Reports. 7: 7761.
Roux O., Vantaux A., Petitclerc F., Orivel J., Dejean A. and Billen J. 2017 Structural adaptations and mechanism of reflex bleeding in the larvae of the myrmecophilous ladybird Diomus thoracicus. Arthropod Structure and Development. 46: 529-536.
Schillewaert S., Parmentier T., Vantaux A., Van den Ende W., Vorburger C. and Wenseleers T. 2017 The influence of facultative endosymbionts on honeydew carbohydrates and amino acid composition of Aphis fabae. Physiological Entomology. 42: 125-133.

2016

Vantaux A., Lefèvre T., Cohuet A., Dabiré K. R., Roche B. and Roux O. 2016 Larval nutritional stress affects vector life history traits and human malaria transmission. Scientific Reports. 6: 36778.
Vantaux A., Ouattara I., Lefèvre T. and Dabiré K. R. 2016 Effects of larvicidal and nutritional stresses on Anopheles gambiae development, survival and competence for Plasmodium falciparum. Parasites & Vectors. 9: 1-11.
Schillewaert S., Vantaux A., Van den Ende W. and Wenseleers T. 2016. The effect of host plants on clonal variability in fitness and honeydew composition of Aphis fabae. Insect Science, 5: 781-788.
Yerbanga R. S., Rayaisse J.-B., Vantaux A., Salou E., Mouline K., de Sales Hien F. D., Habluetzel A., Dabiré K. R., Ouédraogo J. B., Solano P. and Lefèvre T. 2016 Neemazal® as a possible alternative control tool for malaria and African trypanosomiasis? Parasites & Vectors. 9: 1-14.
Carissimo G., Eiglmeier K., Holm I., Diallo M., Diallo D., Vantaux A., Kim S., Ménard D., Reveillaud J., Belda E., Bischoff E., Antoniewski C. and Vernick K. D. 2016 Identification and characterization of two novel RNA viruses from Anopheles gambiae species complex mosquitoes. Plos One. 11: e015388.

2015

Vantaux A., de Sales Hien F. D., Yameogo B., Thomas F., Cohuet A. and Lefèvre T. 2015 Host-seeking behaviors of mosquitoes experimentally infected with sympatric field isolates of the human malaria parasite Plasmodium falciparum: no evidence for host manipulation. Frontiers in Ecology and Evolution. 3:86.
Roux O., Vantaux A., Roche B., Yameogo B., Dabiré K. R., Diabaté A., Simard F. and Lefèvre T. 2015 Evidence for carry-over effects of predator exposure on pathogen transmission potential. Proceedings of the Royal Society B. 282: 20152430.
Vantaux A., Schillewaert S., Parmentier T., Van den Ende W., Billen J. and Wenseleers T. 2015 The cost of ant-attendance and melezitose secretion in the black bean aphid Aphis fabae. Ecological Entomology. 40: 511-517.

2014 and before

Vantaux A., Dabiré K. R., Cohuet A. and Lefèvre T. 2014 A heavy legacy: offspring from malaria-infected mosquitoes show reduced disease resistance. Malaria Journal. 13: 442.
Vantaux A., Lefèvre T., Dabiré K. R. and Cohuet A. 2014 Individual experience affects host choice in malaria vector mosquitoes. Parasites & Vectors. 7, 249.
Lefèvre T., Vantaux A., Dabiré K. R., Mouline K., Cohuet A. 2013 Non-genetic determinants of mosquito competence for malaria parasites. Plos Pathogens. 9, e1003365.
Vantaux A., Parmentier T., Billen J. and Wenseleers T. 2012 Do Lasius niger ants punish low-quality black bean aphid mutualists? Animal Behaviour, 83: 257-262
Vantaux A., Roux O., Magro A. and Orivel J. 2012 Evolutionary perspectives on myrmecophily in ladybirds. Psyche: ID 591570: 7, invited article.
Vantaux A., Billen J. and Wenseleers T. 2011 Levels of clonal mixing in the black bean aphid Aphis fabae, a facultative ant mutualist. Molecular Ecology, 20 : 4772-4785
(Leading to a perspective on it by Dr. Patrick Abbott)
Vantaux A., Van den Ende W., Billen J. and Wenseleers T. 2011. Large clonal differences in melezitose secretion in the facultatively ant-tended black bean aphid Aphis fabae. Journal of Insect Physiology, 57: 1614-1621
Vantaux A., Roux O., Magro A., Ghomsi N. T., Gordon R. D., Dejean A. and Orivel J. 2010 Host-specific myrmecophily and myrmecophagy in the tropical coccinellid Diomus thoracicus. Biotropica, 42: 622-629
Vantaux, A. Dejean A., Dor A. and Orivel J. 2007 Parasitism versus mutualism in the ant-garden parabiosis between Camponotus femoratus and Crematogaster levior. Insectes Sociaux, 54 : 95-99