The Committee of Scientific Animation of Institut Pasteur du Cambodge will organise a seminar on the “The SouthEastAsia Encephalitis Project”.
Speaker: Dr. Christopher Gorman, SEAeProject, WP2 Regional Coordinator, Virology Unit, Institut Pasteur du Cambodge
Date and location: Thursday 17th March 2016 at 2:00pm, IPC’s meeting room, first floor.
Free admission. Any question, please contact us by email: [email protected]
The SEAe (SouthEast Asia encephalitis) Project aims to reduce the morbidity and mortality associated with infectious encephalitis in Southeast Asia by improving diagnosis and medical care for patients. Encephalitis is defined as an acute inflammation of the central nervous system (due to infectious or non-infectious causes) associated with neurologic dysfunction. Due to the high mortality and long-term neurological sequelae, encephalitis remains a public health concern worldwide, and over 50% of cases remain without a laboratory-confirmed diagnosis. To address the ambitious aims of SEAe and reduce the knowledge gap, national centers and hospitals in Cambodia (PP), Lao PDR (Vientiane) and Vietnam (Hanoi) formed partnerships to recruit hospital-admitted patients to undergo a detailed medical examination, neurological imaging, extensive laboratory testing and follow-up studies to better identify the individual and regional causes. In addition, environmental risk factors are assessed to better understand the epidemiological risk factors to the human population.
Across the region, 281 patients have been recruited into the SEAe Project to 04 January 2016. Clinically, 66% of patients experienced seizures and 55% had a focal neurological deficit described. Laboratory-confirmed diagnosis was provided in 59% cases, with JEV (38%), TB (5%) and Scrub Typhus (5%) as principal etiologies. Importantly, these causes represent vaccine-preventable or treatable infections. The outcome of patients was 42% recovery, 42% sequelae and 16% death.
Recruitment remains on-going in the three countries with each hospital recruiting up to 4 patients per week. In March 2016, it is expected that Myanmar (Yangon Children’s’ Hospital) will commence patient recruitment, further expanding the coverage of the SEAe Project. It is hoped that this project will aid in providing a timely and specific medical treatment/care for individuals and providing crucial information to guide public health policy at the regional and country levels.