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RESEARCH

Malaria Molecular Epidemiology

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RESEARCH

Malaria Molecular Epidemiology

For more information about this unit, please contact

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Recent Publications

Primaquine for Plasmodium vivax radical cure: What we do not know and why it matters. Jean Popovici, Kieran Tebben, Benoit Witkowski, David Serre  January 24th, 2021

 

Choosing interventions to eliminate forest malaria: preliminary results of two operational research studies inside Cambodian forests. Amber Kunkel, Chea Nguon, Sophea Iv, Srean Chhim, Dom Peov, Phanith Kong, Saorin Kim, Sarun Im, Mark Debackere, Nimol Khim, Jean Popovici, Sreynet Srun, Amélie Vantaux, Jean-Olivier Guintran, Benoit Witkowski, Patrice Piola January 20th, 2021

 

Keep the quality high: the benefits of lot testing for the quality control of malaria rapid diagnostic tests. Sandra Incardona, David Bell, Ana Campillo, Jane Cunningham, Frederic Ariey, Thierry Fandeur, Jennifer Luchavez, Christian Anthony Luna, Didier Ménard, Sina Nhem, Johanna Beulah Sornillo, Benoit Witkowski, Zachary Katz, Sabine Dittrich, Xavier C Ding  July 13th, 2020

Previous Publications

Clinical and in Vitro Resistance of Plasmodium Falciparum to Artesunate-Amodiaquine in Cambodia : Clin Infect Dis,2020May27, Melissa Mairet-Khedim/ Rithea Leang/ Camille Marmai/ Nimol Khim/ Saorin Kim/ Sopheakvatey Ke/ Chhayleang Kauy/ Nimol Kloeung/ Rotha Eam/, Sophy Chy/ Brigitte Izac/ Denis Mey Bouth/ Maria Dorina Bustos/ Pascal Ringwald/ Frederic Ariey/ Benoit Witkowski

 

Quantification of glucose-6-phosphate dehydrogenase activity by spectrophotometry: A systematic review and meta-analysis : PLoS Med. 2020 May 14, Pfeffer DA / Ley B / Howes RE / Adu P / Alam MS / Bansil P / Boum Y 2nd / Brito M / Charoenkwan P / Clements A / Cui L / Deng Z / Egesie OJ / Espino FE /, von Fricken ME / Hamid MMA / He Y / Henriques G / Khan WA / Khim N / Kim S / Lacerda M / Lon C / Mekuria AH / Menard D / Monteiro W / Nosten F / Oo NN /, ^Pal S / Palasuwan D / Parikh S / Pitaloka Pasaribu A / Poespoprodjo JR / Price DJ / Roca-Feltrer A / Roh ME / Saunders DL / Spring MD / Sutanto I / Ley-Thriemer K /, Weppelmann TA / von Seidlein L / Satyagraha AW / Bancone G / Domingo GJ / Price RN.

 

Pyronaridine-artesunate Efficacy and Safety in Uncomplicated Plasmodium Falciparum Malaria in Areas of Artemisinin-resistant Falciparum in Viet Nam (2017-2018) : Clin Infect Dis ,2020May06, Quang Bui P / Hong Huynh Q / Thanh Tran D / Thanh Le D / Quang Nguyen T / Van Truong H / Khim N / Witkowski B / Cong Tran D / Bustos MD / Ringwald P / Thi Ta T.

 

Tools to accelerate falciparum malaria elimination in Cambodia: a meeting report : Malar J,2020Apr15. Lek D / Callery JJ / Nguon C / Debackere M / Sovannaroth S / Tripura R / Wojnarski M / Piola P / Khean ST / Manion K /, Nguon S / Kunkel A / Vernaeve L / Peto TJ / Dantzer E / Davoeung C / Etienne W / Dondorp AM / Tuseo L / von Seidlein L / Guintran JO.

 

Impact of the first-line treatment shift from dihydroartemisinin/piperaquine to artesunate/mefloquine on Plasmodium vivax drug susceptibility in Cambodia : J Antimicrob Chemother,2020 Mar24, Roesch C / Mairet-Khedim M / Kim S / Lek D / Popovici J / Witkowski B.

 

Plasmodium vivax Liver and Blood Stages Recruit the Druggable Host Membrane Channel Aquaporin-3 : Cell Chem Biol,2020Mar24, Posfai D / Maher SP / Roesch C / Vantaux A / Sylvester K / Péneau J / Popovici J / Kyle DE / Witkowski B / Derbyshire ER.

 

Significant efficacy of single low dose primaquine compared to stand alone artemisinin combination therapy in reducing gametocyte carriage in Cambodian patients with uncomplicated multidrug resistant Plasmodium falciparum malaria : Antimicrob Agents Chemother,2020Mar16, Vantaux A / Kim S / Piv E / Chy S / Berne L / Khim N / Lek D / Siv S / Mukaka M / Taylor WR / Ménard D

 

The enigmatic mechanisms by which Plasmodium vivax infects Duffy-negative individuals : PLoS Pathog,2020Feb20, Popovici J / Roesch C / Rougeron V.

 

Amplification of Duffy binding protein-encoding gene allows Plasmodium vivax to evade host anti-DBP humoral immunity : Nat Commun,2020Feb19, Popovici J / Roesch C / Carias LL / Khim N / Kim S / Vantaux A / Mueller I / Chitnis CE / King CL / Witkowski B.

 

Performance of Ultrasensitive Rapid Diagnostic Tests for Detecting Asymptomatic Plasmodium falciparum : The American Society of Tropical Medicine and Hygiene,2020Feb10, Shunmay Yeung / David McGregor / Nicola James / Soy Ty Kheang / Saorin Kim / Nimol Khim / Po Ly / Siv Sovannaroth / Benoit Witkowski

 

DNA Methylation Bisubstrate Inhibitors Are Fast-Acting Drugs Active against Artemisinin-Resistant Plasmodium falciparum Parasites : ACS Cent Sci,2020 Jan 22, Nardella F / Halby L / Hammam E / Erdmann D / Cadet-Daniel V / Peronet R / Ménard D / Witkowski B / Mecheri S / Scherf A / Arimondo PB

 

2019

Clinical and in Vitro Resistance of Plasmodium Falciparum to Artesunate-Amodiaquine in Cambodia : Clin Infect Dis,2020May27, Melissa Mairet-Khedim/ Rithea Leang/ Camille Marmai/ Nimol Khim/ Saorin Kim/ Sopheakvatey Ke/ Chhayleang Kauy/ Nimol Kloeung/ Rotha Eam/, Sophy Chy/ Brigitte Izac/ Denis Mey Bouth/ Maria Dorina Bustos/ Pascal Ringwald/ Frederic Ariey/ Benoit Witkowski

 

Quantification of glucose-6-phosphate dehydrogenase activity by spectrophotometry: A systematic review and meta-analysis : PLoS Med. 2020 May 14, Pfeffer DA / Ley B / Howes RE / Adu P / Alam MS / Bansil P / Boum Y 2nd / Brito M / Charoenkwan P / Clements A / Cui L / Deng Z / Egesie OJ / Espino FE /, von Fricken ME / Hamid MMA / He Y / Henriques G / Khan WA / Khim N / Kim S / Lacerda M / Lon C / Mekuria AH / Menard D / Monteiro W / Nosten F / Oo NN /, ^Pal S / Palasuwan D / Parikh S / Pitaloka Pasaribu A / Poespoprodjo JR / Price DJ / Roca-Feltrer A / Roh ME / Saunders DL / Spring MD / Sutanto I / Ley-Thriemer K /, Weppelmann TA / von Seidlein L / Satyagraha AW / Bancone G / Domingo GJ / Price RN.

 

Pyronaridine-artesunate Efficacy and Safety in Uncomplicated Plasmodium Falciparum Malaria in Areas of Artemisinin-resistant Falciparum in Viet Nam (2017-2018) : Clin Infect Dis ,2020May06, Quang Bui P / Hong Huynh Q / Thanh Tran D / Thanh Le D / Quang Nguyen T / Van Truong H / Khim N / Witkowski B / Cong Tran D / Bustos MD / Ringwald P / Thi Ta T.

 

Tools to accelerate falciparum malaria elimination in Cambodia: a meeting report : Malar J,2020Apr15. Lek D / Callery JJ / Nguon C / Debackere M / Sovannaroth S / Tripura R / Wojnarski M / Piola P / Khean ST / Manion K /, Nguon S / Kunkel A / Vernaeve L / Peto TJ / Dantzer E / Davoeung C / Etienne W / Dondorp AM / Tuseo L / von Seidlein L / Guintran JO.

 

Impact of the first-line treatment shift from dihydroartemisinin/piperaquine to artesunate/mefloquine on Plasmodium vivax drug susceptibility in Cambodia : J Antimicrob Chemother,2020 Mar24, Roesch C / Mairet-Khedim M / Kim S / Lek D / Popovici J / Witkowski B.

 

Plasmodium vivax Liver and Blood Stages Recruit the Druggable Host Membrane Channel Aquaporin-3 : Cell Chem Biol,2020Mar24, Posfai D / Maher SP / Roesch C / Vantaux A / Sylvester K / Péneau J / Popovici J / Kyle DE / Witkowski B / Derbyshire ER.

 

Significant efficacy of single low dose primaquine compared to stand alone artemisinin combination therapy in reducing gametocyte carriage in Cambodian patients with uncomplicated multidrug resistant Plasmodium falciparum malaria : Antimicrob Agents Chemother,2020Mar16, Vantaux A / Kim S / Piv E / Chy S / Berne L / Khim N / Lek D / Siv S / Mukaka M / Taylor WR / Ménard D

 

The enigmatic mechanisms by which Plasmodium vivax infects Duffy-negative individuals : PLoS Pathog,2020Feb20, Popovici J / Roesch C / Rougeron V.

 

Amplification of Duffy binding protein-encoding gene allows Plasmodium vivax to evade host anti-DBP humoral immunity : Nat Commun,2020Feb19, Popovici J / Roesch C / Carias LL / Khim N / Kim S / Vantaux A / Mueller I / Chitnis CE / King CL / Witkowski B.

 

Performance of Ultrasensitive Rapid Diagnostic Tests for Detecting Asymptomatic Plasmodium falciparum : The American Society of Tropical Medicine and Hygiene,2020Feb10, Shunmay Yeung / David McGregor / Nicola James / Soy Ty Kheang / Saorin Kim / Nimol Khim / Po Ly / Siv Sovannaroth / Benoit Witkowski

 

DNA Methylation Bisubstrate Inhibitors Are Fast-Acting Drugs Active against Artemisinin-Resistant Plasmodium falciparum Parasites : ACS Cent Sci,2020 Jan 22, Nardella F / Halby L / Hammam E / Erdmann D / Cadet-Daniel V / Peronet R / Ménard D / Witkowski B / Mecheri S / Scherf A / Arimondo PB

 

Asymptomatic Plasmodium vivax infections among Duffy-negative population in Kedougou, Senegal : Trop Med Health,2018Dec29, Niang M / Sane R / Sow A / Sadio BD / Chy S / Legrand E / Faye O / Diallo M / Sall AA / Menard D / Toure-Balde A.

 

Genetic diversity in two Plasmodium vivax protein ligands for reticulocyte invasion : PLoS neglected tropical diseases,2018Oct22, Roesch C / Popovici J / Bin S / Run V / Kim S / Ramboarina S / Rakotomalala E / Rakotoarison RL / Rasoloharimanana T / Andriamanantena Z, / Kumar A / Guillotte-Blisnick M / Huon C / Serre D / Chitnis CE / Vigan-Womas I / Menard D

 

Field assessment of potential sugar feeding stations for disseminating bacteria in a paratransgenic approach to control malaria : Malaria journal,2018Oct17, Bilgo E / Vantaux A / Sanon A / Ilboudo S / Dabiré RK / Jacobs-Lorena M / Diabate A

 

Recrudescence, reinfection or relapse? A more rigorous framework to assess chloroquine efficacy for vivax malaria : The Journal of infectious diseases,2018Aug09

Popovici J / Pierce-Friedrich L / Kim S / Bin S / Run V / Lek D / Hor Daryl HK / Lee Soon-U L / Cannon MV / Serre D / Menard D.

 

Importance of household-level risk factors in explaining micro-epidemiology of asymptomatic malaria infections in Ratanakiri Province, Cambodia : Scientific reports,2018Aug03, Bannister-Tyrrell M / Srun S / Sluydts V / Gryseels C / Mean V / Kim S / Sokny M / Peeters Grietens K / Coosemans M / Menard D / Tho S / Van Bortel W / Durnez L.

 

Targeting a Reticulocyte Binding Protein and Duffy Binding Protein to Inhibit Reticulocyte Invasion by Plasmodium vivax : Scientific reports, 2018Jul12, Gupta S / Singh S / Popovici J / Roesch C / Shakri AR / Guillotte-Blisnick M / Huon C / Menard D / Chitnis CE

 

Prevalence and risk factors for asymptomatic malaria and genotyping of glucose 6-phosphate (G6PD) deficiencies in a vivax-predominant setting, Lao PDR: implications for sub-national elimination goals : Malaria journal, 2018Jun01, Lover AA / Dantzer E / Hongvanthong B / Chindavongsa K / Welty S / Reza T / Khim N / Menard D / Bennett A.

 

A comprehensive model for assessment of liver stage therapies targeting Plasmodium vivax and Plasmodium falciparum : Nat Commun, 2018May09, Roth A / Maher SP / Conway AJ / Ubalee R / Chaumeau V / Andolina C / Kaba SA / Vantaux A / Bakowski MA / Luque RT / Adapa SR / Singh N / Barnes SJ / Cooper CA /, Rouillier M / McNamara CW / Mikolajczak SA / Sather N / Witkowski B / Campo B / Kappe SHI / Lanar DE / Nosten F / Davidson S / Jiang RHY / Kyle DE / Adams JH.

 

Endoperoxide-based compounds: cross-resistance with artemisinins and selection of a Plasmodium falciparum lineage with a K13 non-synonymous polymorphism : J Antimicrob Chemother, 2018Feb01, Paloque L / Witkowski B / Lelièvre J / Ouji M / Ben Haddou T / Ariey F / Robert A / Augereau JM / Ménard D / Meunier B / Benoit-Vical F

 

Contribution to malaria transmission of symptomatic and asymptomatic parasite carriers in Cambodia : J Infect Dis, 2018Jan31, Vantaux A / Samreth R / Piv EP / Khim N / Kim S / Berne L / Chy S / Lek D / Siv S / Taylor WR / Ménard D

 

Closing in on the Reservoir: Proactive Case Detection in High-Risk Groups as a Strategy to Detect Plasmodium falciparum Asymptomatic Carriers in Cambodia : Clin Infect Dis, 2018Jan18, Rossi G / Vernaeve L / Van den Bergh R / Nguon C / Debackere M / Abello Peiri C / Van V / Khim N / Kim S / Eam R / Ken M / Khean C / De Smet M / Menard D / Kindermans JM

 

Genomic Analyses Reveal the Common Occurrence and Complexity of Plasmodium vivax Relapses in Cambodia : MBio, 2018Jan23, Popovici J / Friedrich LR / Kim S / Bin S / Run V / Lek D / Cannon MV / Menard D / Serre D

 

Identification and characterization of areas of high and low risk for asymptomatic malaria infections at sub-village level in Ratanakiri, Cambodia : Malaria Journal, 2018Jan15, Durnez L / Pareyn M / Mean V /  Kim S / Khim N /  Menard D / Coosemans M / Sochantha T and Sluydts V

Adapting Reactive Case Detection Strategies for falciparum Malaria in a Low-Transmission Area in Cambodia : Clin Infect Dis, 2018Jan06. Rossi G / Van den Bergh R / Nguon C / Debackere M / Vernaeve L / Khim N / Kim S / Menard D / De Smet M / Kindermans J, 

 

 

2017

Functional analysis of Plasmodium falciparum subpopulations associated with artemisinin resistance in Cambodia : Malar J, 2017Dec19, Dwivedi A / Reynes C / Kuehn A / Roche DB / Khim N / Hebrard M / Milanesi S / Rivals E / Frutos R / Menard D / Mamoun CB / Colinge J / Cornillot E

 

Emergence of Plasmodium falciparum triple mutant in Cambodia : Lancet Infect Dis, 2017Dec17, Rossi G / De Smet M / Khim N / Kindermans JM / Menard D

 

Antiplasmodial activities of dyes against Plasmodium falciparum asexual and sexual stages: Contrasted uptakes of triarylmethanes Brilliant green, Green S (E142), and Patent Blue V (E131) by erythrocytes : Int J Parasitol Drugs Drug Resist, 2017Dec07, Leba LJ / Popovici J / Estevez Y / Pelleau S / Legrand E / Musset L / Duplais C

 

Performance of Rapid Diagnostic Testing in Patients with Suspected Malaria in Cambodia, a Low-Endemicity Country Aiming for Malaria Elimination : Clinical infectious diseases 2017Oct30, Rossi G / De Smet M / Khim N / Kindermans JM / Menard D

 

Correction to: Prevalence of K13 mutation and Day-3 positive parasitaemia in artemisinin-resistant malaria endemic area of Cambodia: a cross-sectional study : Malar J, 2017Oct27, Kheang ST / Sovannaroth S / Ek S / Chy S / Chhun P / Mao S / Nguon S / Lek DS / Menard D / Kak N

 

The effect of host plants on genotype variability in fitness and honeydew composition of Aphis fabae : Insect Sci, 2017Oct24, Schillewaert S / Vantaux A / Van den Ende W / Wenseleers T

 

Prevalence of K13 mutation and Day-3 positive parasitaemia in artemisinin-resistant malaria endemic area of Cambodia: a cross-sectional study : Malar J, 2017Sep13

Kheang ST / Sovannaroth S / Ek S / Chy S / Chhun P / Mao S / Nguon S / Lek DS / Menard D / Kak N

No evidence for manipulation of Anopheles gambiae, An. coluzzii and An. arabiensis host preference by Plasmodium falciparum : Sci Rep, 2017Aug25, Nguyen PL / Vantaux A / Hien DF / Dabiré KR / Yameogo BK / Gouagna LC / Fontenille D / Renaud F / Simard F / Costantini C / Thomas F / Cohuet A / Lefèvre T

 

Characterization of P. vivax blood stage transcriptomes from field isolates reveals similarities among infections and complex gene isoforms : Sci Rep, 2017Aug10, Kim A / Popovici J / Vantaux A / Samreth R / Bin S / Kim S / Roesch C / Liang L / Davies H / Felgner P / Herrera S / Arévalo-Herrera M / Ménard D / Serre D

 

Structural adaptations and mechanism of reflex bleeding in the larvae of the myrmecophilous ladybird Diomus thoracicus : Arthropod Struct Dev, 2017Jul04, Roux O / Vantaux A / Petitclerc F / Orivel J / Dejean A / Billen J

 

The spread of artemisinin-resistant Plasmodium falciparum in the Greater Mekong Subregion: a molecular epidemiology observational study : Lancet Infect Dis, 2017May01, Imwong M / Suwannasin K / Kunasol C / Sutawong K / Mayxay M / Rekol H / Smithuis FM / Hlaing TM / Tun KM / van der Pluijm RW / Tripura R / Miotto O /, Menard D / Dhorda M / Day NP / White NJ / Dondorp AM

 

Emergence of Indigenous Artemisinin-Resistant Plasmodium falciparum in Africa : The New England journal of medicine, 2017Mar09, Lu F / Culleton R / Zhang M / Ramaprasad A / von Seidlein L / Zhou H / Zhu G / Tang J / Liu Y /, Wang W / Cao Y / Xu S / Gu Y / Li J / Zhang C / Gao Q / Menard D / Pain A / Yang H / Zhang Q / Cao J

 

Antimalarial Drug Resistance: A Threat to Malaria Elimination : Cold Spring Harb Perspect Med, 2017Mar13, Menard D / Dondorp A

 

A surrogate marker of piperaquine-resistant Plasmodium falciparum malaria: a phenotype-genotype association study : Lancet Infect Dis, 2017Feb04, Witkowski B / Duru V / Khim N / Ross LS / Saintpierre B / Beghain J / Chy S / Kim S / Ke S / Kloeung N / Eam R / Khean C / Ken M / Loch K / Bouillon A / Domergue A /, Ma L / Bouchier C / Leang R / Huy R / Nuel G / Barale JC / Legrand E / Ringwald P / Fidock DA / Mercereau-Puijalon O / Ariey F / Ménard D.

 

Modelling primaquine-induced haemolysis in G6PD deficiency : Elife, 2017Feb04, Watson J / Taylor WR / Menard D / Kheng S / White NJ

Prevalence, numbers and antimicrobial susceptibilities of Salmonella serovars and Campylobacter spp. in retail poultry in Phnom Penh, Cambodia. Lay KS, Vuthy Y, Song P, Phol K, Sarthou. J Vet Med Sci. 2011 Mar;73(3):325-9. Epub 2010 Nov 2.

Plasmodium vivax Malaria in Cambodia : Am J Trop Med Hyg, 2016Dec28Siv S / Roca-Feltrer A / Vinjamuri SB / Bouth DM / Lek D / Rashid MA / By NP / Popovici J / Huy R / Menard D / …….

 

Flavone derivatives: a promising tool in the fight against malaria : Planta Med, 2016Dec, Nardella F / Stiebing S / Wagner P / Collot V / Kaiser M / Witkowski B / Menard D / Schmitt M / Candolfi E / Vonthron-Sénécheau C

 

Plasmodium vivax multidrug resistance-1 gene polymorphism in French Guiana : Malar J, 2016Nov8, ,Faway E / Musset L / Pelleau S1 / Volney B / Casteras J1 / Caro V / Menard D / Briolant S / Legrand E

 

A surrogate marker of piperaquine-resistant Plasmodium falciparum malaria: a phenotype-genotype association study : Lancet Infect Dis, 2016Nov3, Witkowski B / Duru V / Khim N / Ross LS / Saintpierre B / Beghain J / Chy S / Kim S / Ke S / Kloeung N / Eam R / Khean C / Ken M / Loch K / …….

 

Plasmodium falciparum Resistance to Artemisinin Derivatives and Piperaquine: A Major Challenge for Malaria Elimination in Cambodia : Am J Trop Med Hyg, 2016Dec7

Duru V / Witkowski B / Ménard D

An optimised age-based dosing regimen for single low-dose primaquine for blocking malaria transmission in Cambodia, Leang R / Khu NH / Mukaka M / Debackere M / Tripura R / Kheang ST / Chy S / Kak N / Buchy P / Tarantola A / Menard D / Roca-Felterer A / …….

 

Serological markers to measure recent changes in malaria at population level in Cambodia, Kerkhof K / Sluydts V / Willen L / Kim S / Canier L / Heng S / Tsuboi T / Sochantha T / Sovannaroth S / Ménard D / Coosemans M / Durnez L / ……

 

Geographical patterns of malaria transmission based on serological markers for falciparum and vivax malaria in Ratanakiri, Cambodia : Malar J. 2016 Oct 19, Kerkhof K / Sluydts V / Heng S / Kim S / Pareyn M / Willen L / Canier L / Sovannaroth S / Ménard D / Sochantha T / Coosemans M / Durnez L

 

Efficacy of topical mosquito repellent (picaridin) plus long-lasting insecticidal nets versus long-lasting insecticidal nets alone for control of malaria: a cluster randomised controlled trial : Lancet Infect Dis, 2016Oct, (PDF FORMAT) Vincent Sluydts / PhD / Lies Durnez / PhD / Somony Heng / MD / Charlotte Gryseels / MSc / Lydie Canier / MSc / Saorin Kim / BSc / …….

National Malaria Prevalence in Cambodia: Microscopy Versus Polymerase Chain Reaction Estimates : Am J Trop Med Hyg, 2016Sep7. Lek D / Popovici J / Ariey F / Vinjamuri SB / Meek S / Bruce J / Taylor WR / Socheat D / Menard D / Rogers WO

Artemisinin-Resistant Plasmodium falciparum K13 Mutant Alleles, Thailand-Myanmar Border : Emerg Infect Dis, 2016Aug, Boullé M / Witkowski B / Duru V / Sriprawat K / Nair SK / McDew-White M / Anderson TJ / Phyo AP / Menard D / Nosten F

 

A Worldwide Map of Plasmodium falciparum K13-Propeller Polymorphisms : N Engl J Med, 2016Jun23, Ménard D / Khim N / Beghain J / Adegnika AA / Shafiul-Alam M / Amodu O / Rahim-Awab G / Barnadas C / Berry A / Boum Y / Bustos MD / Cao J / …….

 

Plasmodium falciparum parasite population structure and gene flow associated to anti‑malarial drugs resistance in Cambodia : Malar J, 2016Jun14, Ankit Dwivedi / Nimol Khim / Christelle Reynes / Patrice Ravel / Laurence Ma / Magali Tichit / Christiane Bourchier / Saorin Kim / …….

 

Low-grade sulfadoxine-pyrimethamine resistance in Plasmodium falciparum parasites from Lubango, Angola : Malar J, 2016Jun7, Kaingona-Daniel EP / Gomes LR / Gama BE / Almeida-de-Oliveira NK / Fortes F / Ménard D / Daniel-Ribeiro CT / Ferreira-da-Cruz Mde F

 

Ape malaria transmission and potential for ape-to-human transfers in Africa : Proc Natl Acad Sci U S A, 2016May10, Makanga B / Yangari P / Rahola N / Rougeron V / Elguero E / Boundenga L / Moukodoum ND / Okouga AP / Arnathau C / Durand P / …….

 

Multiple and successive treatment failures in a patient infected by Plasmodium falciparum in Cambodia and treated by dihydroartemisinin-piperaquine : Bull Soc Pathol Exot, 2016May, Witkowski B / Khim N / Kim S / Domergue A / Duru V / Menard D

 

Identification and Characterization of Two Novel RNA Viruses from Anopheles gambiae Species Complex Mosquitoes : PLoS One, 2016May3, Carissimo G / Eiglmeier K / Reveillaud J / Holm I / Diallo M / Diallo D / Vantaux A / Kim S / Ménard D / Siv S / Belda E / Bischoff E /…….

 

An updated checklist of mosquito species (Diptera: Culicidae) from Madagascar : Parasite 2016 (PDF FORMAT), Michaël Luciano Tantely / Gilbert Le Goff / Sébastien Boyer / Didier Fontenille

 

Plasmodium copy number variation scan: gene copy numbers evaluation in haploid genomes : Malar J, 2016Apr12, Beghain J / Langlois AC / Legrand E / Grange L / Khim N / Witkowski B / Duru V / Ma L / Bouchier C / Ménard D / Paul RE / Ariey F

 

Complexity of Infection and Genetic Diversity in Cambodian Plasmodium vivax : PLoS Negl Trop Dis, 2016Mar28 (PDF FORMAT ), Friedrich LR / Popovici J / Kim S / Dysoley L / Zimmerman PA / Menard D / Serre D

 

Reactive case-detection of malaria in Pailin Province, Western Cambodia: lessons from a year-long evaluation in a pre-elimination setting: Malar J, 2016Mar01, Hustedt J / Canavati SE / Rang C / Ashton RA / Khim N / Berne L / Kim S / Sovannaroth S / Ly P / Ménard D / Cox J / Meek S / Roca-Feltrer A

 

Efficacy and safety of pyronaridine-artesunate for the treatment of uncomplicated Plasmodium falciparum malaria in western Cambodia, Leang R / Canavati SE / Khim N / Vestergaard LS / Borghini Fuhrer I / Kim S / Denis MB / Heng P / Tol B / Huy R / Duparc S / Dondorp AM / …….

Plasmodium Vivax Mdr1 Genotypes in Isolates from Successfully Cured Patients Living in Endemic and Non-Endemic Brazilian Areas : Malar J, 2016Feb18.  Gomes / L. R. / N. K. Almeida-de-Oliveira / A. R. de Lavigne / S. R. de Lima / A. de Pina-Costa / P. Brasil / C. T. Daniel-Ribeiro / D. Menard / ……

 

2015

Malaria rapid diagnostic test as point-of-care test: study protocol for evaluating the VIKIA® Malaria Ag Pf/Pan. Saorin Kim, Sina Nhem, Dany Dourng and Didier Ménard. Kim et al. Malaria Journal (2015) 14:114, DOI 10.1186/s12936-015-0633-3, March 14, 2015

 

K13-Propeller Polymorphisms in Plasmodium Falciparum Isolates from Patients in Mayotte in 2013 and 2014. Torrentino-Madamet, M., L. Collet, J. F. Lepere, N. Benoit, R. Amalvict, D. Menard and B. Pradines. “K13-Propeller Polymorphisms in Plasmodium Falciparum Isolates from Patients in Mayotte in 2013 and 2014.” Antimicrob Agents Chemother 59, no. 12 (2015): 7878-81.

 

Independent Emergence of Artemisinin Resistance Mutations among Plasmodium Falciparum in Southeast Asia. Takala-Harrison, S., C. G. Jacob, C. Arze, M. P. Cummings, J. C. Silva, A. M. Dondorp, M. M. Fukuda, T. T. Hien, M. Mayxay, H. Noedl, F. Nosten, M. P. Kyaw, N. T. Nhien, M. Imwong, D. Bethell, Y. Se, C. Lon, S. D. Tyner, D. L. Saunders, F. Ariey, O. Mercereau-Puijalon, D. Menard, P. N. Newton, M. Khanthavong, B. Hongvanthong, P. Starzengruber, H. P. Fuehrer, P. Swoboda, W. A. Khan, A. P. Phyo, M. M. Nyunt, M. H. Nyunt, T. S. Brown, M. Adams, C. S. Pepin, J. Bailey, J. C. Tan, M. T. Ferdig, T. G. Clark, O. Miotto, B. MacInnis, D. P. Kwiatkowski, N. J. White, P. Ringwald and C. V. Plowe.  J Infect Dis 211, no. 5 (2015): 670-9.

 

Drug Resistance. K13-Propeller Mutations Confer Artemisinin Resistance in Plasmodium Falciparum Clinical Isolates. Straimer, J., N. F. Gnadig, B. Witkowski, C. Amaratunga, V. Duru, A. P. Ramadani, M. Dacheux, N. Khim, L. Zhang, S. Lam, P. D. Gregory, F. D. Urnov, O. Mercereau-Puijalon, F. Benoit-Vical, R. M. Fairhurst, D. Menard and D. A. Fidock.  Science 347, no. 6220 (2015): 428-31.

 

Challenges in Antimalarial Drug Treatment for Vivax Malaria Control. Popovici, J. and D. Menard.  Trends Mol Med 21, no. 12 (2015): 776-88.

Reduced Polymorphism in the Kelch Propeller Domain in Plasmodium Vivax Isolates from Cambodia. Popovici, J., S. Kao, L. Eal, S. Bin, S. Kim and D. Menard.  Antimicrob Agents Chemother 59, no. 1 (2015): 730-3.

 

Low Frequency of Acute Hepatitis E Virus (Hev) Infections but High Past Hev Exposure in Subjects from Cambodia with Mild Liver Enzyme Elevations, Unexplained Fever or Immunodeficiency Due to Hiv-1 Infection. Nouhin J, Barennes H, Madec Y, Prak S, Hou SV, Kerleguer A, Kim S, Pean P, Rouet F. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2015, 71:22-27.

 

Genetic Diversity of Human Rhinoviruses in Cambodia During a Three-Year Period Reveals Novel Genetic Types. Naughtin, M., R. Sareth, A. C. Sentilhes, S. Vong, M. L. Joffret, E. Cornillot, V. Deubel, F. Delpeyroux, R. Frutos and P. Buchy.  Infect Genet Evol 35,  (2015): 42-9.

 

Towards Real-Time Monitoring of Artemisinin Resistance. Menard, D. and F. Ariey. Lancet Infect Dis 15, no. 4 (2015): 367-8.

 

Histone Methyltransferase Inhibitors Are Orally Bioavailable, Fast-Acting Molecules with Activity against Different Species Causing Malaria in Humans. Malmquist, N. A., S. Sundriyal, J. Caron, P. Chen, B. Witkowski, D. Menard, R. Suwanarusk, L. Renia, F. Nosten, M. B. Jimenez-Diaz, I. Angulo-Barturen, M. Santos Martinez, S. Ferrer, L. M. Sanz, F. J. Gamo, S. Wittlin, S. Duffy, V. M. Avery, A. Ruecker, M. J. Delves, R. E. Sinden, M. J. Fuchter and A. Scherf.  Antimicrob Agents Chemother 59, no. 2 (2015): 950-9.

 

Use of Plasmodium Falciparum Culture-Adapted Field Isolates for in Vitro Exflagellation-Blocking Assay. Leba, L. J., L. Musset, S. Pelleau, Y. Estevez, C. Birer, S. Briolant, B. Witkowski, D. Menard, M. J. Delves, E. Legrand, C. Duplais and J. Popovici.  Malar J 14,  (2015): 234.

 

Evidence of Plasmodium Falciparum Malaria Multidrug Resistance to Artemisinin and Piperaquine in Western Cambodia: Dihydroartemisinin-Piperaquine Open-Label Multicenter Clinical Assessment. Leang, R., W. R. Taylor, D. M. Bouth, L. Song, J. Tarning, M. C. Char, S. Kim, B. Witkowski, V. Duru, A. Domergue, N. Khim, P. Ringwald and D. Menard.  Antimicrob Agents Chemother 59, no. 8 (2015): 4719-26.

 

Plasmodium Vivax Diversity and Population Structure across Four Continents. Koepfli, C., P. T. Rodrigues, T. Antao, P. Orjuela-Sanchez, P. Van den Eede, D. Gamboa, N. van Hong, J. Bendezu, A. Erhart, C. Barnadas, A. Ratsimbasoa, D. Menard, C. Severini, M. Menegon, B. Y. Nour, N. Karunaweera, I. Mueller, M. U. Ferreira and I. Felger. PLoS Negl Trop Dis 9, no. 6 (2015): e0003872.

 

Tolerability and Safety of Weekly Primaquine against Relapse of Plasmodium Vivax in Cambodians with Glucose-6-Phosphate Dehydrogenase Deficiency. Kheng, S., S. Muth, W. R. Taylor, N. Tops, K. Kosal, K. Sothea, P. Souy, S. Kim, C. M. Char, C. Vanna, P. Ly, P. Ringwald, V. Khieu, A. Kerleguer, P. Tor, J. K. Baird, S. Bjorge, D. Menard and E. Christophel. BMC Med 13,  (2015): 203.

 

Implementation and Application of a Multiplex Assay to Detect Malaria-Specific Antibodies: A Promising Tool for Assessing Malaria Transmission in Southeast Asian Pre-Elimination Areas. Kerkhof, K., L. Canier, S. Kim, S. Heng, T. Sochantha, S. Sovannaroth, I. Vigan-Womas, M. Coosemans, V. Sluydts, D. Menard and L. Durnez.  Malar J 14,  (2015): 338.

 

Novel Cross-Border Approaches to Optimise Identification of Asymptomatic and Artemisinin-Resistant Plasmodium Infection in Mobile Populations Crossing Cambodian Borders. Edwards, H. M., S. E. Canavati, C. Rang, P. Ly, S. Sovannaroth, L. Canier, N. Khim, D. Menard, R. A. Ashton, S. R. Meek and A. Roca-Feltrer.  PLoS One 10, no. 9 (2015): e0124300.

 

Plasmodium Falciparum Dihydroartemisinin-Piperaquine Failures in Cambodia Are Associated with Mutant K13 Parasites Presenting High Survival Rates in Novel Piperaquine in Vitro Assays: Retrospective and Prospective Investigations. Duru, V., N. Khim, R. Leang, S. Kim, A. Domergue, N. Kloeung, S. Ke, S. Chy, R. Eam, C. Khean, K. Loch, M. Ken, D. Lek, J. Beghain, F. Ariey, P. J. Guerin, R. Huy, O. Mercereau-Puijalon, B. Witkowski and D. Menard.  BMC Med 13,  (2015): 305.

 

Malaria Pcr Detection in Cambodian Low-Transmission Settings: Dried Blood Spots Versus Venous Blood Samples. Canier, L., N. Khim, S. Kim, R. Eam, C. Khean, K. Loch, M. Ken, P. Pannus, P. Bosman, J. Stassijns, F. Nackers, S. Alipon, M. C. Char, N. Chea, W. Etienne, M. De Smet, J. M. Kindermans and D. Menard.  Am J Trop Med Hyg 92, no. 3 (2015): 573-7.

 

Value of Routine Dengue Diagnostic Tests in Urine and Saliva Specimens. Andries, A. C., V. Duong, S. Ly, J. Cappelle, K. S. Kim, P. Lorn Try, S. Ros, S. Ong, R. Huy, P. Horwood, M. Flamand, A. Sakuntabhai, A. Tarantola and P. Buchy.  PLoS Negl Trop Dis 9, no. 9 (2015): e0004100.

Field evaluation of picaridin repellents reveals differences in repellent sensitivity between Southeast Asian vectors of malaria and arboviruses. Van Roey K, Sokny M, Denis L, Van den Broeck N, Heng S, Siv S, Sluydts V, Sochantha T, Coosemans M, Durnez L. PLoS Negl Trop Dis. 2014 Dec 18;8(12):e3326. doi: 10.1371/journal.pntd.0003326. eCollection 2014.

 

[Towards a better understanding of the molecular mechanisms of P. falciparum resistance to artemisinin]. Khim N, Witkowski B, Duru V, Ariey F, Mercereau-Puijalon O, Ménard D.  Med Sci (Paris). 2014 Aug-Sep;30(8-9):727-9. doi: 10.1051/medsci/20143008004. Epub 2014 Sep 1.

 

Plasmodium falciparum founder populations in western Cambodia have reduced artemisinin sensitivity in vitro. Amaratunga C, Witkowski B, Dek D, Try V, Khim N, Miotto O, Ménard D, Fairhurst RM. Antimicrob Agents Chemother. 2014 Aug;58(8):4935-7. do: 10.1128/AAC.03055-14. Epub 2014 May 27.

 

Genetic diversity of VAR2CSA ID1-DBL2Xb in worldwide Plasmodium falciparum populations: impact on vaccine design for placental malaria. Bordbar B, Tuikue Ndam N, Renard E, Jafari-Guemouri S, Tavul L, Jennison C, Gnidehou S, Tahar R, Gamboa D, Bendezu J, Menard D, Barry AE, Deloron P, Sabbagh A. Infect Genet Evol. 2014 Jul;25:81-92. doi: 10.1016/j.meegid.2014.04.010. Epub 2014 Apr 21.

 

Acute undifferentiated febrile illness in rural Cambodia: a 3-year prospective observational study. Mueller TC, Siv S, Khim N, Kim S, Fleischmann E, Ariey F, Buchy P, Guillard B, González IJ, Christophel EM, Abdur R, von Sonnenburg F, Bell D, Menard D. PLoS One. 2014 Apr 22;9(4):e95868. doi: 10.1371/journal.pone.0095868.

 

A molecular marker of artemisinin-resistant Plasmodium falciparum malaria. Ariey F, Witkowski B, Amaratunga C, Beghain J, Langlois AC, Khim N, Kim S, Duru V, Bouchier C, Ma L, Lim P, Leang R, Duong S, Sreng S, Suon S, Chuor CM, Bout DM, Ménard S, Rogers WO, Genton B, Fandeur T, Miotto O, Ringwald P, Le Bras J, Berry, Barale JC, Fairhurst RM, Benoit-Vical F, Mercereau-Puijalon O, Ménard D. Nature. 2014 Jan 2;505(7481):50-5. doi: 10.1038/nature12876. Epub 2013 Dec 18.

 

2013

Whole genome sequencing of field isolates reveals a common duplication of the Duffy binding protein gene in Malagasy Plasmodium vivax strains. Menard D, Chan ER, Benedet C, Ratsimbasoa A, Kim S, Chim P, Do C, Witkowski B, Durand R, Thellier M, Severini C, Legrand E, Musset L, Nour BY, Mercereau-Puijalon O, Serre D, Zimmerman PA. PLoS Negl Trop Dis. 2013 Nov 21;7(11):e2489. doi: 10.1371/journal.pntd.0002489. eCollection 2013.

 

An innovative tool for moving malaria PCR detection of parasite reservoir into the field. Canier L, Khim N, Kim S, Sluydts V, Heng S, Dourng D, Eam R, Chy S, Khean C, Loch K, Ken M, Lim H, Siv S, Tho S, Masse-Navette P, Gryseels C, Uk S, Van Roey K, Grietens KP, Sokny M, Thavrin B, Chuor CM, Deubel V, Durnez L, Coosemans M, Ménard D. Malar J. 2013 Nov 9;12:405. doi: 10.1186/1475-2875-12-405.

 

Therapeutic efficacy of fixed dose artesunate-mefloquine for the treatment of acute, uncomplicated Plasmodium falciparum malaria in Kampong Speu, Cambodia. Leang R, Ros S, Duong S, Navaratnam V, Lim P, Ariey F, Kiechel JR, Ménard D, Taylor WR (2013). Malar J. 2013 Sep 23;12(1):343.

 

Novel phenotypic assays for the detection of artemisinin-resistant Plasmodium falciparummalaria in Cambodia: in-vitro and ex-vivo drug-response studies. Witkowski B, Amaratunga C, Khim N, Sreng S, Chim P, Kim S, Lim P, Mao S, Sopha C, Sam B, Anderson JM, Duong S, Meng Chuor C, Taylor WRJ, Suon S, Mercereau-Puijalon O, Fairhurst M, Menard D (2013).  Lancet Infect Dis. 2013 Sep 10.

 

Ex vivo susceptibility of Plasmodium falciparum to antimalarial drugs in western, northern, and eastern Cambodia, 2011-2012: association with molecular markers. Lim P, Dek D, Try V, Eastman RT, Chy S, Sreng S, Suon S, Mao S, Sopha C, Sam B, Ashley EA, Miotto O, Dondorp AM, White NJ, Su XZ, Chuor CM, Anderson JM, Amaratunga C, Menard D, Fairhurst RM (2013).  Antimicrob Agents Chemother. 2013 Aug 12.

 

High-Throughput Analysis of Antimalarial Susceptibility Data by the WorldWide Antimalarial Resistance Network (WWARN) In Vitro Analysis and Reporting Tool. Woodrow CJ, Dahlström S, Cooksey R, Flegg JA, Le Nagard H, Mentré F, Murillo C, Ménard D, Nosten F, Sriprawat K, Musset L, Quashie NB, Lim P, Fairhurst RM, Nsobya SL, Sinou V, Noedl H, Pradines B, Johnson JD, Guerin PJ, Sibley CH, Le Bras J. (2013). Antimicrob Agents Chemother. 2013 Jul;57(7):3121-30.

 

The Evolutionary History of Plasmodium vivax as Inferred from Mitochondrial Genomes: Parasite Genetic Diversity in the Americas. Taylor JE, Pacheco MA, Bacon DJ, Beg MA, Machado RL, Fairhurst RM, Herrera S, Kim JY, Menard D, Póvoa MM, Villegas L, Mulyanto, Snounou G, Cui L, Zeyrek FY, Escalante AA. (2013). The Evolutionary History of Plasmodium vivax as Inferred from Mitochondrial Genomes: Parasite Genetic Diversity in the Americas. Mol Biol Evol. 2013 Jun 28.

 

In Silico Screening on the Three-dimensional Model of the Plasmodium vivax SUB1 Protease Leads to the Validation of a Novel Anti-parasite Compound. Bouillon A, Giganti D, Benedet C, Gorgette O, Pêtres S, Crublet E, Girard-Blanc C, Witkowski B, Ménard D, Nilges M, Mercereau-Puijalon O, Stoven V, Barale JC. (2013). J Biol Chem. 2013 Jun 21;288(25):18561-73.

 

Plasmodium falciparum susceptibility to antimalarial drugs: global data issued from the Pasteur Institutes international network. Ménard D, Ariey F, Mercereau-Puijalon O. Plasmodium falciparum susceptibility to antimalarial drugs: global data issued from the Pasteur Institutes international network. Med Sci (Paris). 2013 Jun-Jul;29(6-7):647-55.

 

G6PD deficiency inPlasmodium falciparum and Plasmodium vivax malaria-infected Cambodian patients. Khim N, Benedet C, Kim S, Kheng S, Siv S, Leang R, Lek S, Muth S, Chea N, Chuor CM, Duong S, Kerleguer A, Tor P, Chim P, Canier L, Witkowski B, Taylor WR, Ménard D. (2013). G6PD deficiency inPlasmodium falciparum and Plasmodium vivax malaria-infected Cambodian patients. Malar J. 2013 May 28;12(1):171.

 

Review of key knowledge gaps in glucose-6-phosphate dehydrogenase deficiency detection with regard to the safe clinical deployment of 8-aminoquinoline treatment regimens: a workshop report. Von Seidlein L, Auburn S, Espino F, Shanks D, Cheng Q, McCarthy J, Baird K, Moyes C, Howes R, Ménard D, Bancone G, Winasti-Satyahraha A, Vestergaard LS, Green J, Domingo G, Yeung S, Price R. (2013).  Malar J. 2013 Mar 27;12:112.

 

Reduced Artemisinin Susceptibility of Plasmodium falciparum Ring Stages in Western Cambodia. Witkowski B , Khim N , Chim P , Kim S , Ke S , Kloeung N , Chy S , Duong S, Leang R, Ringwald P, Dondorp AM, Tripura R, Benoit-Vical F, Berry A, Gorgette O, Ariey F, Barale JC, Mercereau-Puijalon O, Menard D. (2013).   Antimicrob Agents Chemother. 2013 Feb;57(2):914-23.

 

Efficacy of Dihydroartemisinin-Piperaquine for Treatment of Uncomplicated Plasmodium falciparum and Plasmodium vivax in Cambodia, 2008 to 2010. Leang R, Barrette A, Bouth DM, Menard D , Abdur R, Duong S, Ringwald P. (2013).  Antimicrob Agents Chemother. 2013 Feb;57(2):818-26.

 

Plasmodium falciparum Na+/H+ Exchanger (pfnhe-1) Genetic Polymorphism in Indian Ocean Malaria-Endemic Areas. Andriantsoanirina V, Khim N , Ratsimbasoa A, Witkowski B , Benedet C , Canier L , Bouchier C, Tichit M, Durand R, Ménard D. (2013). Am J Trop Med Hyg. 2013 Jan;88(1):37-42.

 

 

2012

Effect of High-Dose or Split-Dose Artesunate on Parasite Clearance in Artemisinin-Resistant Falciparum Malaria. Das D, Tripura R, Phyo AP, Lwin KM, Tarning J, Lee SJ, Hanpithakpong W, Stepniewska K, Menard D ,Ringwald P, Silamut K, Imwong M, Chotivanich K, Yi P, Day NP, Lindegardh N, Socheat D, Nguon C, White NJ, Nosten F, Dondorp AM. (2013).  Clin Infect Dis. 2012 Dec 21.

 

Global analysis of Plasmodium falciparum Na+/H+ exchanger (pfnhe-1) allele polymorphism and its usefulness as a marker of in vitro resistance to quinine. Didier Ménard , Valérie Andriantsoanirina, Nimol Khim , Arsène Ratsimbasoa, Benoit Witkowski ,Christophe Benedet , Lydie Canier, Odile Mercereau-Puijalon, Rémy Durand (2012).  International Journal for Parasitology: Drugs and Drug Resistance, Volume 3, December 2012, Pages 8-19.

 

Mapping the Aetiology of Non-Malarial Febrile Illness in Southeast Asia through a Systematic Review-Terra Incognita Impairing Treatment Policies. Nathalie Acestor, Richard Cooksey, Paul N Newton, Didier Ménard, Philippe J Guerin, Jun Nakagawa, Eva Christophel, Iveth J González, David Bell (2012). PLoS One 7: 9. 09

 

Performance of “VIKIA Malaria Ag Pf/Pan” (IMACCESS®), a new malaria rapid diagnostic test for detection of symptomatic malaria infections. Monidarin Chou, Saorin Kim , Nimol Khim, Sophy Chy, Sarorn Sum, Dany Dourng, Lydie Canier, Chea Nguon, Didier Menard (2012).  Malar J 11: 1. Aug

 

Fluoroquinolone and pyrazinamide resistance in multidrug-resistant tuberculosis. Pierre-Audigier C, Surcouf C, Cadet-Daniel V, Namouchi A, Heng S, Murray A, Guillard B, Gicquel B. Int J Tuberc Lung Dis. 2012 Feb;16(2):221-3.

 

Individual Pvmsp1 variants within polyclonal Plasmodium vivax infections display different propensities for relapse. Jessica T Lin, Jonathan J Juliano, Oksana Kharabora, Rithy Sem, Feng-Chang Lin, Sinuon Muth, Didier Ménard, Chansuda Wongsrichanalai, William O Rogers, Steven R Meshnick (2012).  J Clin Microbiol Dec.

 

Management of uncomplicated malaria in febrile under five-year-old children by community health workers in Madagascar: reliability of malaria rapid diagnostic tests. Arsene Ratsimbasoa, Harintsoa Ravony, Jeanne-Aimee Vonimpaisomihanta, Rogelin Raherinjafy, Martial Jahevitra, Rabenja Rapelanoro, Jean De Dieu Marie Rakotomanga, Denis Malvy, Pascal Millet, Didier Menard (2012).  Malar J 11: 1. Mar  

 

Whole Genome Sequencing of Field Isolates Provides Robust Characterization of Genetic Diversity in Plasmodium vivax. Ernest R Chan, Didier Menard , Peter H David, Arsène Ratsimbasoa, Saorin Kim, Pheaktra Chim, Catherine Do, Benoit Witkowski, Odile Mercereau-Puijalon, Peter A Zimmerman, David Serre (2012).  PLoS Negl Trop Dis 6: 9. Sep  

 

Compliance, Safety, and Effectiveness of Fixed-Dose Artesunate-Amodiaquine for Presumptive Treatment of Non-Severe Malaria in the Context of Home Management of Malaria in Madagascar. Arsène Ratsimbasoa, Harintsoa Ravony, Jeanne-Aimée Vonimpaisomihanta, Rogelin Raherinjafy, Martial Jahevitra, Rabenja Rapelanoro, Jean De Dieu Marie Rakotomanga, Denis Malvy, Pascal Millet, Didier Ménard (2012).  Am J Trop Med Hyg 86: 2. 203-210

 

Focused Screening and Treatment (FSAT): a PCR-based strategy to detect malaria parasite carriers and contain drug resistant P. falciparum, Pailin, Cambodia. F Hoyer S, Nguon S, Kim S , Habib N, Khim N , Sum S , Christophel EM, Bjorge S, Thomson A, Kheng S, Chea N, Yok S, Top S, Ros S, Sophal U, Thompson MM, Mellor S, Ariey F , Witkowski B , Yeang C, Yeung S, Duong S, Newman RD, Menard D . (2012).  PLoS One. 2012;7(10):e45797.

 

Performance of the CareStart™ G6PD deficiency screening test, a point-of-care diagnostic for primaquine therapy screening. Kim S, Nguon C, Guillard B, Duong S, Chy S, Sum S, Nhem S, Bouchier C, Tichit M, Christophel E, Taylor WR, Baird JK, Menard D.  PLoS One. 2011;6(12):e28357. doi: 10.1371/journal.pone.0028357. Epub 2011 Dec 2.

 

Reduced impact of pyrimethamine drug pressure on Plasmodium malariae dihydrofolate reductase gene. Nimol Khim, Saorin Kim, Christiane Bouchier, Magali Tichit, Frédéric Ariey, Thierry Fandeur, Pheaktra Chim, Sopheakvatey Ke, Sarorn Sum, Somnang Man, Arsène Ratsimbasoa, Rémy Durand, Didier Ménard (2011).  Antimicrob Agents Chemother Nov

 

In vitro susceptibility to pyrimethamine of DHFR I164L single mutant Plasmodium falciparum. Andriantsoanirina V, Durand R, Pradines B, Baret E, Bouchier C, Ratsimbasoa A, Menard D.  Malar J. 2011 Sep 27;10(1):283

 

Resistance of Plasmodium falciparum to antimalarial drugs: impact on malaria pre-elimination in Madagascar. Andriantsoanirina V, Ménard D, Tuséo L, Ratsimbasoa A, Durand R.  Med Trop . 2011 Jun;71(3):298-304.

 

The global distribution of the Duffy blood group. Howes RE, Patil AP, Piel FB, Nyaniri OA, Kabaria CW, Gething PW, Zimmerman PA, Barnadas C, Beall CM, Gebremedhin A, Ménard D, Williams TN, Weatherall DJ, Hay SI.  Nat Commun. 2011 Apr;2:266.

 

Multiple independent introductions of Plasmodium falciparum in South America. Erhan Yalcindag, Eric Elguero, Céline Arnathau, Patrick Durand, Jean Akiana, Timothy J Anderson, Agnes Aubouy, François Balloux, Patrick Besnard, Hervé Bogreau, Pierre Carnevale, Umberto D’Alessandro, Didier Fontenille, Dionicia Gamboa, Thibaut Jombart, Jacques Le Mire, Eric Leroy, Amanda Maestre, Mayfong Mayxay, Didier Ménard, Lise Musset, Paul N Newton, Dieudonné Nkoghé, Oscar Noya, Benjamin Ollomo, Christophe Rogier, Vincent Veron, Albina Wide, Sedigheh Zakeri, Bernard Carme, Eric Legrand, Christine Chevillon, Francisco J Ayala, François Renaud, Franck Prugnolle (2011)  Proc Natl Acad Sci U S A Dec  

 

Plasmodium knowlesi Infection in Humans, Cambodia, 2007-2010. Nimol Khim , Sovannaroth Siv, Saorin Kim, Tara Mueller, Erna Fleischmann, Balbir Singh, Paul Cliff Simon Divis, Nicolas Steenkeste, Linda Duva l, Christiane Bouchier, Socheat Duong, Frederic Ariey ,Didier Menard (2011).  Emerg Infect Dis 17: 10. 1900-1902 Oct   

 

2010

Exposing malaria in-host diversity and estimating population diversity by capture-recapture using massively parallel pyrosequencing. Juliano JJ, Porter K, Mwapasa V, Sem R, Rogers WO, Ariey F, Wongsrichanalai C, Read A, Meshnick SR.  Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):20138-43.

 

Chloroquine clinical failures in P. falciparum malaria are associated with mutant Pfmdr-1, not Pfcrt in Madagascar. Andriantsoanirina V, Ratsimbasoa A, Bouchier C, Tichit M, Jahevitra M, Rabearimanana S, Raherinjafy R, Mercereau-Puijalon O, Durand R, Ménard D.  PLoS One. 2010 Oct 13;5(10):e13281.

 

Plasmodium vivax and the Duffy antigen: A paradigm revisited. Mercereau-Puijalon O, Ménard D.  Transfus Clin Biol. 2010 Sep;17(3):176-183.

 

Heritability of the human infectious reservoir of malaria parasites. Lawaly YR, Sakuntabhai A, Marrama L, Konate L, Phimpraphi W, Sokhna C, Tall A, Sarr FD, Peerapittayamongkol C, Louicharoen C, Schneider BS, Levescot A, Talman A, Casademont I, Menard D, Trape JF, Rogier C, Kaewkunwal J, Sura T, Nuchprayoon I, Ariey F, Baril L, Singhasivanon P, Mercereau-Puijalon O, Paul R.  PLoS One. 2010 Jun 29;5(6):e11358.

 

African apes as reservoirs of Plasmodium falciparum and the origin and diversification of the Laverania subgenus. Duval L, Fourment M, Nerrienet E, Rousset D, Sadeuh SA, Goodman SM, Andriaholinirina NV, Randrianarivelojosia M, Paul RE, Robert V, Ayala FJ, Ariey F.  Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10561-6.

 

OPV strains circulation in HIV infected infants after National Immunisation Days in Bangui, Central African Republic. Manirakiza A, Picard E, Ngbale R, Menard D, Gouandjika-Vasilache I.  BMC Res Notes. 2010 May 18;3:136.

 

Global sequence variation in the histidine-rich proteins 2 and 3 of Plasmodium falciparum: implications for the performance of malaria rapid diagnostic tests. Baker J, Ho MF, Pelecanos A, Gatton M, Chen N, Abdullah S, Albertini A, Ariey F, Barnwell J, Bell D, Cunningham J, Djalle D, Echeverry DF, Gamboa D, Hii J, Kyaw MP, Luchavez J, Membi C, Menard D, Murillo C, Nhem S, Ogutu B, Onyor P, Oyibo W, Wang SQ, McCarthy J, Cheng Q.  Malar J. 2010 May 17;9:129.

 

Decreased in vitro susceptibility of Plasmodium falciparum isolates to artesunate, mefloquine, chloroquine, and quinine in Cambodia from 2001 to 2007. Lim P, Wongsrichanalai C, Chim P, Khim N, Kim S, Chy S, Sem R, Nhem S, Yi P, Duong S, Bouth DM, Genton B, Beck HP, Gobert JG, Rogers WO, Coppee JY, Fandeur T, Mercereau-Puijalon O, Ringwald P, Le Bras J, Ariey F.  Antimicrob Agents Chemother. 2010 May;54(5):2135-42.

 

Sub-microscopic malaria cases and mixed malaria infection in a remote area of high malaria endemicity in Rattanakiri province, Cambodia: implication for malaria elimination. Steenkeste N, Rogers WO, Okell L, Jeanne I, Incardona S,Duval L, Chy S, Hewitt S, Chou M, Socheat D, Babin FX, Ariey F, Rogier C.  Malar J. 2010 Apr 22;9:108.

 

Plasmodium vivax clinical malaria is commonly observed in Duffy-negative Malagasy people. Ménard D, Barnadas C, Bouchier C, Henry-Halldin C, Gray LR, Ratsimbasoa A, Thonier V, Carod JF, Domarle O, Colin Y, Bertrand O, Picot J, King CL, Grimberg BT, Mercereau-Puijalon O, Zimmerman PA.  Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):5967-71.

 

Origin and evolution of sulfadoxine resistant Plasmodium falciparum. Vinayak S, Alam MT, Mixson-Hayden T, McCollum AM, Sem R, Shah NK, Lim P, Muth S, Rogers WO, Fandeur T, Barnwell JW, Escalante AA, Wongsrichanalai C, Ariey F F, Meshnick SR, Udhayakumar V.  PLoS Pathog. 2010 Mar 26;6(3):e1000830.

 

Origins of the recent emergence of Plasmodium falciparum pyrimethamine resistant alleles into Madagascar. Andriantsoanirina V, Bouchier C, Tichit M, Jahevitra M, Rabearimanana S, Randrianjafy R, Ratsimbasoa A, Mercereau-Puijalon O, Durand R, Ménard D.  Antimicrob Agents Chemother. 2010 Mar 22.

 

Geographic structuring of the Plasmodium falciparum sarco(endo)plasmic reticulum Ca2+ ATPase (PfSERCA) gene diversity. Jambou R, Martinelli A, Pinto J, Gribaldo S, Legrand E, Niang M, Kim N, Pharath L, Volnay B, Ekala MT, Bouchier C, Fandeur T, Berzosa P, Benito A, Ferreira ID, Ferreira C, Vieira PP, Alecrim MG, Mercereau-Puijalon O, Cravo P.  PLoS One. 2010 Feb 25;5(2):e9424.

 

Multiple genetic backgrounds of the amplified Plasmodium falciparum multidrug resistance (pfmdr1) gene and selective sweep of 184F mutation in Cambodia. Vinayak S, Alam MT, Sem R, Shah NK, Susanti AI, Lim P, Muth S, Maguire JD, Rogers WO, Fandeur T, Barnwell JW, Escalante AA, Wongsrichanalai C, Ariey F F, Meshnick SR, Udhayakumar V. J Infect Dis. 2010 May 15;201(10):1551-60.

 

Residual antimalarial concentrations before treatment in patients with malaria from Cambodia: indication of drug pressure. Hodel EM, Genton B, Zanolari B, Mercier T, Duong S, Beck HP, Olliaro P, Decosterd LA, Ariey F. Residual antimalarial concentrations before treatment in patients with malaria from Cambodia: indication of drug pressure. J Infect Dis. 2010 Oct 1;202(7):1088-94.

 

History and current status of Plasmodium falciparum antimalarial drug resistance in Madagascar. Andriantsoanirina V, Ménard D, Tuseo L, Durand R. Scand J Infect Dis. 2010;42(1):22-32.

 

Microsatellite variations of Plasmodium falciparum Na+/H+ exchanger (Pfnhe-1) gene are not associated with reduced in vitro susceptibility to quinine in clinical isolates from Africa. Andriantsoanirina V, Ménard D, Rabearimanana S, Hubert V, Bouchier C, Tichit M, LeBras J, Durand R.  Am J Trop Med Hyg. 2010.

 

Low-technology cooling box for storage of malaria RDTs and other medical supplies in remote areas. Chanthap L, Ariey F F, Socheat D, Tsuyuoka R, Bell D.  Malar J. 2010 Jan 23;9:31.

 

2009

A microarray-based system for the simultaneous analysis of single nucleotide polymorphisms in human genes involved in the metabolism of anti-malarial drugs. Hodel EM, Ley SD, Qi W, Ariey F F, Genton B, Beck HP.  Malar J. 2009 Dec 9;8:285.

 

Artemisinin resistance in Plasmodium falciparum malaria. Dondorp AM, Nosten F, Yi P, Das D, Phyo AP, Tarning J, Lwin KM, Ariey F F, Hanpithakpong W, Lee SJ, Ringwald P, Silamut K, Imwong M, Chotivanich K, Lim P, Herdman T, An SS, Yeung S, Singhasivanon P, Day NP, Lindegardh N, Socheat D, White NJ.  N Engl J Med. 2009 Jul 30;361(5):455-67. Erratum in: N Engl J Med. 2009 Oct 22;361(17):1714.

 

FlexiChip package: an universal microarray with a dedicated analysis software for high-thoughput SNPs detection linked to anti-malarial drug resistance. Steenkeste N , Dillies MA, Khim N , Sismeiro O, Chy S , Lim P , Crameri A, Bouchier C, Mercereau-Puijalon O, Beck HP, Imwong M, Dondorp AM, Socheat D, Rogier C, Coppée JY, Ariey F F.  Malar J. 2009 Oct 15;8:229.

 

Misclassification of drug failure in Plasmodium falciparum clinical trials in southeast Asia. Juliano JJ, Ariey F F, Sem R, Tangpukdee N, Krudsood S, Olson C, Looareesuwan S, Rogers WO, Wongsrichanalai C, Meshnick SR.  J Infect Dis. 2009 Aug 15;200(4):624-8.

 

Towards high-throughput molecular detection of Plasmodium: new approaches and molecular markers. Steenkeste N, Incardona S, Chy S, Duval L, Ekala MT, Lim P, Hewitt S, Sochantha T, Socheat D, Rogier C, Mercereau-Puijalon O, Fandeur T, Ariey F F.  Malar J. 2009 Apr 29;8:86.

 

Chimpanzee malaria parasites related to Plasmodium ovale in Africa. Duval L , Nerrienet E, Rousset D, Sadeuh Mba SA, Houze S, Fourment M, Le Bras J, Robert V, Ariey F F.  PLoS One. 2009;4(5):e5520.

 

Pfmdr1 copy number and arteminisin derivatives combination therapy failure in falciparum malaria in Cambodia. Lim P, Alker AP, Khim N, Shah NK, Incardona S, Doung S, Yi P, Bouth DM, Bouchier C, Puijalon OM, Meshnick SR, Wongsrichanalai C, Fandeur T, Le Bras J, Ringwald P, Ariey F F.  Malar J. 2009 Jan 12;8:11.

 

Failure of artesunate-mefloquine combination therapy for uncomplicated Plasmodium falciparum malaria in southern Cambodia. Rogers WO, Sem R, Tero T, Chim P, Lim P, Muth S, Socheat D, Ariey F F, Wongsrichanalai C.  Malar J. 2009 Jan 12;8:10.

 

2008

Molecular surveillance for multidrug-resistant Plasmodium falciparum, Cambodia. Shah NK, Alker AP, Sem R , Susanti AI, Muth S, Maguire JD, Duong S, Ariey F F, Meshnick SR, Wongsrichanalai C.  Emerg Infect Dis. 2008 Oct;14(10):1637-40.

 

Attraction between sexes: male-female gametocyte behaviour within a Leucocytozoon toddi (Haemosporida). Barraclough RK, Duval L, Talman AM, Ariey F F, Robert V.  Parasitol Res. 2008 May;102(6):1321-7.

 

2007

Sequence analysis of Plasmodium falciparum cytochrome b in multiple geographic sites. Ekala MT, Khim N, Legrand E, Randrianarivelojosia M, Jambou R, Fandeur T, Menard D, Assi SB, Henry MC, Rogier C, Bouchier C, Mercereau-Puijalon O.  Malar J. 2007 Dec 17;6:164.

 

Evaluation of the intra- and inter-specific genetic variability of Plasmodium lactate dehydrogenase. Talman AM, Duval L, Legrand E, Hubert V, Yen S, Bell D, Le Bras J, Ariey F F, Houze S.  Malar J. 2007 Oct 25;6:140.

 

World Antimalarial Resistance Network (WARN) II: in vitro antimalarial drug susceptibility. Bacon DJ, Jambou R, Fandeur T, Le Bras J, Wongsrichanalai C, Fukuda MM, Ringwald P, Sibley CH, Kyle DE.  Malar J. 2007 Sep 6;6:120.

 

Pfmdr1 and in vivo resistance to artesunate-mefloquine in falciparum malaria on the Cambodian-Thai border. Alker AP, Lim P, Sem R , Shah NK, Yi P, Bouth DM, Tsuyuoka R, Maguire JD, Fandeur T, Ariey F F, Wongsrichanalai C, Meshnick SR.  Am J Trop Med Hyg. 2007 Apr;76(4):641-7.

 

Large-scale malaria survey in Cambodia: novel insights on species distribution and risk factors. Incardona S, Vong S, Chiv L, Lim P, Nhem S, Sem R, Khim N, Doung S, Mercereau-Puijalon O,Fandeur T.  Malar J. 2007 Mar 27;6:37.

 

Rapid dissemination of Plasmodium falciparum drug resistance despite strictly controlled antimalarial use. Noranate N, Durand R, Tall A, Marrama L, Spiegel A, Sokhna C, Pradines B, Cojean S, Guillotte M, Bischoff E, Ekala MT, Bouchier C, Fandeur T , Ariey F F, Patarapotikul J, Le Bras J, Trape JF, Rogier C, Mercereau-Puijalon O. PLoS One. 2007 Jan 3;2(1):e139.

 

2006

Efficacy of artemether-lumefantrine for the treatment of uncomplicated falciparum malaria in northwest Cambodia. Denis MB, Tsuyuoka R, Lim P, Lindegardh N, Yi P, Top SN, Socheat D, Fandeur T, Annerberg A, Christophel EM, Ringwald P.  Trop Med Int Health. 2006 Dec;11(12):1800-7.

 

Design and synthesis of hydroxyferroquine derivatives with antimalarial and antiviral activities. Biot C, Daher W, Chavain N, Fandeur T, Khalife J, Dive D, De Clercq E.  J Med Chem. 2006 May 4;49(9):2845-9.

 

Invasion of Africa by a single pfcrt allele of South East Asian type. Ariey F F, Fandeur T, Durand R, Randrianarivelojosia M, Jambou R, Legrand E, Ekala MT, Bouchier C, Cojean S, Duchemin JB, Robert V, Le Bras J, Mercereau-Puijalon O.  Malar J. 2006 Apr 26;5:34.

 

Assessment of Plasmodium falciparum resistance to ferroquine (SSR97193) in field isolates and in W2 strain under pressure. Daher W, Biot C, Fandeur T, Jouin H, Pelinski L, Viscogliosi E, Fraisse L, Pradines B, Brocard J, Khalife J, Dive D.  Malar J. 2006 Feb 7;5:11.

 

2005

Resistance of Plasmodium falciparum field isolates to in-vitro artemether and point mutations of the SERCA-type PfATPase6. Jambou R, Legrand E, Niang M, Khim N , Lim P , Volney B, Ekala MT, Bouchier C, Esterre P, Fandeur T, Mercereau-Puijalon O.  Lancet. 2005 Dec 3;366(9501):1960-3.

 

Countrywide survey shows very high prevalence of Plasmodium falciparum multilocus resistance genotypes in Cambodia. Khim N, Bouchier C, Ekala MT, Incardona S, Lim P, Legrand E, Jambou R, Doung S, Puijalon OM,Fandeur T.  Antimicrob Agents Chemother. 2005 Aug;49(8):3147-52.

 

Large sequence heterogeneity of the small subunit ribosomal RNA gene of Plasmodium ovale in Cambodia. Incardona S, Chy S, Chiv L, Nhem S, Sem R, Hewitt S, Doung S, Mercereau-Puijalon O, Fandeur T. Am J Trop Med Hyg. 2005 Jun;72(6):719-24.

 

In vitro monitoring of Plasmodium falciparum susceptibility to artesunate, mefloquine, quinine and chloroquine in Cambodia: 2001-2002. Lim P, Chim P, Sem R, Nemh S, Poravuth Y, Lim C, Seila S, Tsuyuoka R, Denis MB, Socheat D, Fandeur T.  Acta Trop. 2005 Jan;93(1):31-40.

 

2004

Importance of protection of antimalarial combination therapies. Duong S, Lim P, Fandeur T, Tsuyuoka R, Wongsrichanalai C.  Lancet. 2004 Nov 13-19;364(9447):1754-5.

 

Variations in the sequence and expression of the Plasmodium falciparum chloroquine resistance transporter (Pfcrt) and their relationship to chloroquine resistance in vitro. Durrand V, Berry A, Sem R, Glaziou P, Beaudou J, Fandeur T. Mol Biochem Parasitol. 2004 Aug;136(2):273-85.

 

The in-vitro antimalarial activity of ferrochloroquine, measured against Cambodian isolates of Plasmodium falciparum. Chim P, Lim P, Sem R, Nhem S, Maciejewski L, Fandeur T.  Ann Trop Med Parasitol. 2004 Jun;98(4):419-24.

 

Chemoresistance and polymorphism in falciparum malaria in Cambodia. Kim N, Bouchier C, Ekala MT, Mercereau-Puijalon O, Fandeur T.  Med Mal Infect. 2004 Jun;34 Suppl 1:S61-4.

 

2003

Antimalarial activity of artemisinins: identification of a novel target? Mercereau-Puijalon O, Fandeur T. Antimalarial activity of artemisinins: identification of a novel target? Lancet. 2003 Dec 20;362(9401):2035-6.

 

Update of malaria, multi-drug resistance and economic development in the Mekong region of Southeast Asia. Socheat D, Denis MB, Fandeur T, Zhang Z, Yang H, Xu J, Zhou X, Phompida S, Phetsouvanh R, Lwin S, Lin K, Win T, Than SW, Htut Y, Prajakwong S, Rojanawatsirivet C, Tipmontree R, Vijaykadga S, Konchom S, Cong le D, Thien NT, Thuan le K, Ringwald P, Schapira A, Christophel E, Palmer K, Arbani PR, Prasittisuk C, Rastogi R, Monti F, Urbani C, Tsuyuoka R, Hoyer S, Otega L, Thimasarn K, Songcharoen S, Meert JP, Gay F, Crissman L, Cho-Min-Naing, Chansuda W, Darasri D, Indaratna K, Singhasivanon P, Chuprapawan S, Looareesuwan S, Supavej S, Kidson C, Baimai V, Yimsamran S, Buchachart K. Mekong malaria. II.  Southeast Asian J Trop Med Public Health. 2003;34 Suppl 4:1-102.

 

pfcrt polymorphism and chloroquine resistance in Plasmodium falciparum strains isolated in Cambodia. Lim P, Chy S, Ariey F, Incardona S, Chim P, Sem R, Denis MB, Hewitt S, Hoyer S, Socheat D, Merecreau-Puijalon O, Fandeur T.  Antimicrob Agents Chemother. 2003 Jan;47(1):87-94.

 

Efficacy and safety of dihydroartemisinin-piperaquine (Artekin) in Cambodian children and adults with uncomplicated falciparum malaria. Denis MB, Davis TM, Hewitt S, Incardona S, Nimol K, Fandeur T, Poravuth Y, Lim C, Socheat D.  Clin Infect Dis. 2002 Dec 15;35(12):1469-76.