Publication from the Immunology, Virology and Epidemiology and Public Health research units in Nature
Researchers from Institut Pasteur du Cambodge recently published a new manuscript aimed to understand better the functional changes in anti-dengue antibody titers during and after dengue virus infection.
We characterized in detail antibodies from plasma from asymptomatic dengue patients and dengue patients that required hospitalization after infection. Anti-dengue antibodies were measured and their functions, such as in vitro neutralization, in vitro antibody-dependent enhancement and in vitro binding to dengue-infected cells was assessed. We found that the amount of anti-dengue antibodies that bound to dengue-infected cells was associated to disease severity in hospitalized patients. Taken together, our data offer insights for more comprehensive interpretation of antibody response profile to natural infection and its correlation to disease outcome.
Link to the publication