The Immunology unit of the Institut Pasteur du Cambodge (IPC) recently published an article entitled “Immune profiling in subclinical secondary dengue-infected cases reveals adaptive immune signatures correlated to protection from severe dengue” in “Cell Host & Microbe”.
Why do some individuals develop severe dengue while others only have subclinical infection is an intense field of investigation over the past decades. Dr. Cantaert’s team contributes to resolve this problem by identifying adaptive immune pathways associated to subclinical dengue during secondary infection. The data provide direct evidence for a protective role of CD4+ and CD8+ T cell subsets during secondary DENV infection, supporting the development of T cell directed interventions.
In collaboration with Kampong Thom provincial and district Hospitals, Jayavarman VII children’s hospital, National center for Parasitology, Entomology and Vector control, Milena Hasan and Anavaj Sakuntabhai from Institut Pasteur in Paris and Tineke Cantaert, Giorgio Gonnella, Emanuele Gioacchino duong veasna and everyone else from Institut Pasteur du Cambodge.
Check the publication: Cell Host & Microbe https://www.sciencedirect.com/science/article/pii/S1931312825002355?ref=pdf_download&fr=RR-2&rr=95a09c065dc2ba69