In collaboration with the Department of Virology at The Centre Pasteur du Cameroun, researchers from the Virology Unit at the Institut Pasteur du Cambodge – both members of the Pasteur Network – analyzed blood samples from patients with hepatitis C in Cameroon. The study aimed to characterize the HCV genetic diversity and to explore the presence of additional virus agents.

Using advanced genome sequencing technology (Oxford Nanopore Technologies), the team identified six near-complete genomes of human pegivirus 2 (HPgV-2). While HPgV-2 is not currently known to cause disease, it is often detected in individuals with hepatitis C.

This study provides further genomic data of HPgV-2 in Africa, contributing to a better understanding of its global distribution, genetic diversity, and evolutionary dynamics. It also highlights the value of cutting-edge sequencing technologies in enhancing viral detection and strengthening surveillance systems.

Importantly, this work reflects the strength and strategic importance of South-South collaboration within the Pasteur Network, demonstrating how partnership between institutions in low- and middle-income countries can drive high-quality research, build local capacity, and address regionally relevant infectious disease challenges.

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Erik Karlsson, Janin Nouhin, Vireak Heang, Leakhena PUM, Centre Pasteur du Cameroun (CPC)