Rethinking Triple Artemisinin-based Therapies against Plasmodium falciparum
Rethinking Triple Artemisinin-based Therapies against Plasmodium falciparum A study published in Nature Communications shows that clinical P. falciparum isolates from Cambodia with resistance to the antimalarial drug mefloquine also tolerate the mefloquine-piperaquine combination, one of the backbone regimens proposed in triple artemisinin-based therapies (TACTs). The team found that pre-existing mefloquine resistance alone was enough to compromise the efficacy of this partner-drug combo … Read more
