Non-coding Genetic Changes Linked to Drug Tolerance in Plasmodium vivax
Non-coding Genetic Changes Linked to Drug Tolerance in Plasmodium vivax Another Nature Communications paper reports a common DNA deletion immediately downstream of the mdr1 gene in P. vivax parasites from Cambodian patients. Unlike classic resistance mutations that alter protein sequences, this 837-base-pair deletion lies in a non-coding region and does not change the mdr1 protein itself, but it does alter the 3’ untranslated region (UTR) of the gene’s … Read more
